Misplaced Pages

SPNS2
Identifiers
Aliases	SPNS2, sphingolipid transporter 2, SLC62A2, DFNB115, SLC63A2
External IDs	OMIM: 612584; MGI: 2384936; HomoloGene: 71040; GeneCards: SPNS2; OMA:SPNS2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 4,498,881 bp End 4,539,035 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B4 Start 72,342,464 bp End 72,380,730 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx C1 segment skin of arm buccal mucosa cell renal medulla right lung inferior ganglion of vagus nerve right frontal lobe upper lobe of left lung Brodmann area 9 Top expressed in esophagus lip muscle of thigh triceps brachii muscle gastrocnemius muscle sternocleidomastoid muscle temporal muscle knee joint mesenteric lymph nodes medial head of gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function sphingolipid transporter activity Cellular component integral component of membrane vesicle lysosomal membrane membrane Biological process lymphocyte homeostasis regulation of humoral immune response regulation of eye pigmentation lipid transport lymph node development B cell homeostasis bone development lymphocyte migration locomotion transmembrane transport sphingosine-1-phosphate receptor signaling pathway sphingolipid metabolic process T cell homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124976 216892 Ensembl ENSG00000183018 ENSMUSG00000040447 UniProt Q8IVW8 Q91VM4 RefSeq (mRNA) NM_001124758 NM_001276383 NM_153060 RefSeq (protein) NP_001118230 NP_001263312 NP_694700 Location (UCSC) Chr 17: 4.5 – 4.54 Mb Chr 11: 72.34 – 72.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene.

Model organisms

The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular development, and human SPNS2 can transport S1P analogues, including the immunomodulating drug FTY720-P.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000183018 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040447 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Spinster homolog 2 (Drosophila)". Retrieved 2011-12-04.
6. Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (January 2009). "The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors". Science. 323 (5913): 524–7. Bibcode:2009Sci...323..524K. doi:10.1126/science.1167449. PMID 19074308. S2CID 44826764.
7. Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T (January 2011). "The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720". The Journal of Biological Chemistry. 286 (3): 1758–66. doi:10.1074/jbc.M110.171116. PMC 3023470. PMID 21084291.

This article on a gene on human chromosome 17 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 17
• Human proteins
• Genes mutated in mice
• Human chromosome 17 gene stubs