Misplaced Pages

SPOCK2
Identifiers
Aliases	SPOCK2, testican-2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
External IDs	OMIM: 607988; MGI: 1891351; HomoloGene: 8854; GeneCards: SPOCK2; OMA:SPOCK2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q22.1 Start 72,059,034 bp End 72,089,032 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B4 Start 59,942,041 bp End 59,971,020 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum lateral nuclear group of thalamus right hemisphere of cerebellum Brodmann area 10 spinal ganglia cerebellar vermis middle frontal gyrus dorsal motor nucleus of vagus nerve pars compacta superior vestibular nucleus Top expressed in habenula entorhinal cortex dorsomedial hypothalamic nucleus perirhinal cortex superior colliculus CA3 field medial dorsal nucleus central gray substance of midbrain subiculum dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding glycosaminoglycan binding extracellular matrix binding metalloendopeptidase inhibitor activity collagen binding Cellular component extracellular region extracellular matrix extracellular space Biological process regulation of cell differentiation synapse assembly peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix organization signal transduction positive regulation of cell-substrate adhesion negative regulation of endopeptidase activity positive regulation of cell motility cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9806 94214 Ensembl ENSG00000107742 ENSMUSG00000058297 UniProt Q92563 Q9ER58 RefSeq (mRNA) NM_001134434 NM_001244950 NM_014767 NM_052994 RefSeq (protein) NP_001127906 NP_001231879 NP_055582 NP_443720 Location (UCSC) Chr 10: 72.06 – 72.09 Mb Chr 10: 59.94 – 59.97 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.

Function

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000107742 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000058297 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vannahme C, Schübel S, Herud M, Gösling S, Hülsmann H, Paulsson M, Hartmann U, Maurer P (July 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". Journal of Neurochemistry. 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID 10386950. S2CID 21955542.
6. ^ "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2".

Further reading

• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. CiteSeerX 10.1.1.319.3770. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nakada M, Miyamori H, Yamashita J, Sato H (June 2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Research. 63 (12): 3364–9. PMID 12810672.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 10 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 10
• Testicans
• Human chromosome 10 gene stubs