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Protein sprouty homolog 3 is a protein that in humans is encoded by the SPRY3 gene.

The SPRY3 gene is one of the genes found in the pseudoautosomal regions of the human sex chromosomes (i.e. those 19 genes that are found on both the X and Y chromosome). It is located in the PAR2 region.

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (Feb 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049.
4. "Entrez Gene: SPRY3 sprouty homolog 3 (Drosophila)".

Further reading

• Ciccodicola A, D'Esposito M, Esposito T, et al. (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
• Lim J, Wong ES, Ong SH, et al. (2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". J. Biol. Chem. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
• Lim J, Yusoff P, Wong ES, et al. (2002). "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes". Mol. Cell. Biol. 22 (22): 7953–66. doi:10.1128/MCB.22.22.7953-7966.2002. PMC 134720. PMID 12391162.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Anteby EY, Natanson-Yaron S, Greenfield C, et al. (2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
• De Bonis ML, Cerase A, Matarazzo MR, et al. (2006). "Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications". Hum. Mol. Genet. 15 (7): 1123–32. doi:10.1093/hmg/ddl027. PMID 16500999.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.

External links

• SPRY3 human gene location in the UCSC Genome Browser.
• SPRY3 human gene details in the UCSC Genome Browser.

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• Human genes
• SPR domain
• Human proteins
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