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SRGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Identifiers
Aliases	SRGAP3, ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase activating protein 3
External IDs	OMIM: 606525; MGI: 2152938; HomoloGene: 56686; GeneCards: SRGAP3; OMA:SRGAP3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.3 Start 8,980,591 bp End 9,363,053 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E3 Start 112,694,932 bp End 112,924,227 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 paraflocculus of cerebellum Brodmann area 10 frontal pole right uterine tube endothelial cell Region I of hippocampus proper Brodmann area 46 postcentral gyrus Top expressed in subiculum pontine nuclei superior colliculus cingulate gyrus piriform cortex dentate gyrus cerebellar vermis lateral septal nucleus hippocampus proper anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm cytosol Biological process negative regulation of cell migration regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9901 259302 Ensembl ENSG00000196220 ENSMUSG00000030257 UniProt O43295 Q812A2 RefSeq (mRNA) NM_001033116 NM_001033117 NM_014850 NM_080448 NM_153070 RefSeq (protein) NP_001028289 NP_055665 NP_536696 Location (UCSC) Chr 3: 8.98 – 9.36 Mb Chr 6: 112.69 – 112.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000196220 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030257 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A. 99 (18): 11754–9. Bibcode:2002PNAS...9911754E. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.
6. "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Wong K, Ren XR, Huang YZ, et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway". Cell. 107 (2): 209–21. doi:10.1016/S0092-8674(01)00530-X. PMID 11672528. S2CID 2458943.
• Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
• Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388. S2CID 1423222.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Yang Y, Marcello M, Endris V, et al. (2006). "MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation". Exp. Cell Res. 312 (12): 2379–93. doi:10.1016/j.yexcr.2006.04.001. PMID 16730001.

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