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SRSF2

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Protein-coding gene in humans
SRSF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2KN4, 2LEA, 2LEB, 2LEC

Identifiers
AliasesSRSF2, PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2
External IDsOMIM: 600813; MGI: 98284; HomoloGene: 37721; GeneCards: SRSF2; OMA:SRSF2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for SRSF2Genomic location for SRSF2
Band17q25.1Start76,734,115 bp
End76,737,333 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for SRSF2Genomic location for SRSF2
Band11 E2|11 81.49 cMStart116,849,901 bp
End116,853,094 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • embryo

  • tendon of biceps brachii

  • thymus

  • ventricular zone

  • ganglionic eminence

  • granulocyte

  • male germ cell

  • sperm

  • lymph node
Top expressed in
  • corneal stroma

  • otic placode

  • tail of embryo

  • otic vesicle

  • Ileal epithelium

  • superior surface of tongue

  • genital tubercle

  • medial ganglionic eminence

  • saccule

  • lactiferous gland
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6427

20382

Ensembl

ENSG00000161547

ENSMUSG00000034120

UniProt

Q01130

Q62093

RefSeq (mRNA)

NM_001195427
NM_003016

NM_011358

RefSeq (protein)

NP_001182356
NP_003007

NP_035488

Location (UCSC)Chr 17: 76.73 – 76.74 MbChr 11: 116.85 – 116.85 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.

Interactions

SFRS2 has been shown to interact with CDC5L and ASF/SF2.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000161547Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034120Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, et al. (September 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–79. doi:10.1006/geno.1995.1216. PMID 8530103.
  6. Fu XD, Maniatis T (April 1992). "Isolation of a complementary DNA that encodes the mammalian splicing factor SC35". Science. 256 (5056): 535–538. Bibcode:1992Sci...256..535F. doi:10.1126/science.1373910. PMID 1373910.
  7. "Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2".
  8. Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, et al. (October 2022). "Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms". Leukemia. 36 (10): 2499–2508. doi:10.1038/s41375-022-01672-4. PMID 35941213. S2CID 251408524.
  9. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  10. Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–5408. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q01130 (Serine/arginine-rich splicing factor 2) at the PDBe-KB.
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