Misplaced Pages

ST8SIA6
Identifiers
Aliases	ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139; MGI: 2386797; HomoloGene: 17112; GeneCards: ST8SIA6; OMA:ST8SIA6 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.33 Start 17,315,421 bp End 17,454,595 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A1 Start 13,655,832 bp End 13,798,875 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad substantia nigra apex of heart left ventricle right auricle epithelium of colon lung thymus white blood cell Top expressed in conjunctival fornix transitional epithelium of urinary bladder substantia nigra epithelium of stomach hair follicle cornea lateral septal nucleus lacrimal gland ciliary body lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity sialyltransferase activity glycosyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process glycolipid biosynthetic process sialylation protein glycosylation protein O-linked glycosylation glycoprotein metabolic process oligosaccharide metabolic process ganglioside biosynthetic process carbohydrate biosynthetic process blastocyst hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338596 241230 Ensembl ENSG00000148488 ENSMUSG00000003418 UniProt P61647 Q8K4T1 RefSeq (mRNA) NM_001004470 NM_001345961 NM_145838 RefSeq (protein) NP_001004470 NP_001332890 NP_665837 Location (UCSC) Chr 10: 17.32 – 17.45 Mb Chr 2: 13.66 – 13.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 ).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000148488 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000003418 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

Further reading

• Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734. S2CID 7578193.
• Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 10
• Human chromosome 10 gene stubs