Steroidogenic acute regulatory protein is a protein that in humans is encoded by the STAR gene.
Function
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. .
References
- ^ GRCh38: Ensembl release 89: ENSG00000147465 – Ensembl, May 2017
- ^ GRCm38: Ensembl release 89: ENSMUSG00000031574 – Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Steroidogenic acute regulatory protein". Retrieved 2018-06-24.
Further reading
- Stocco DM (May 2002). "Clinical disorders associated with abnormal cholesterol transport: mutations in the steroidogenic acute regulatory protein". Mol. Cell. Endocrinol. 191 (1): 19–25. doi:10.1016/s0303-7207(02)00048-5. PMID 12044915. S2CID 23614656.
- Tuckey RC, Headlam MJ, Bose HS, Miller WL (December 2002). "Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR)". J. Biol. Chem. 277 (49): 47123–8. doi:10.1074/jbc.M206965200. PMID 12372832.
- Mathieu AP, Lavigne P, LeHoux JG (November 2002). "Molecular modeling and structure-based thermodynamic analysis of the StAR protein". Endocr. Res. 28 (4): 419–23. doi:10.1081/erc-120016817. PMID 12530644. S2CID 25030552.
- Tajima K, Dantes A, Yao Z, Sorokina K, Kotsuji F, Seger R, Amsterdam A (May 2003). "Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1". J. Clin. Endocrinol. Metab. 88 (5): 2288–99. doi:10.1210/jc.2002-020913. PMID 12727988.
- Kim HJ, Kim JE, Ha M, Kang SS, Kim JT, Park IS, Paek SH, Jung HW, Kim DG, Cho GJ, Choi WS (July 2003). "Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors". Brain Res. 978 (1–2): 245–9. doi:10.1016/s0006-8993(03)02840-3. PMID 12834921. S2CID 32869169.
- Kohen P, Castro O, Palomino A, Muñoz A, Christenson LK, Sierralta W, Carvallo P, Strauss JF, Devoto L (July 2003). "The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase". J. Clin. Endocrinol. Metab. 88 (7): 3421–30. doi:10.1210/jc.2002-021916. PMID 12843197.
- Sugawara T, Shimizu H, Hoshi N, Nakajima A, Fujimoto S (October 2003). "Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system". J. Biol. Chem. 278 (43): 42487–94. doi:10.1074/jbc.M302291200. PMID 12909641.
- Sun HS, Hsiao KY, Hsu CC, Wu MH, Tsai SJ (September 2003). "Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor". Endocrinology. 144 (9): 3934–42. doi:10.1210/en.2003-0289. PMID 12933667.
- Li J, Feltzer RE, Dawson KL, Hudson EA, Clark BJ (December 2003). "Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells". J. Biol. Chem. 278 (52): 52355–62. doi:10.1074/jbc.M305232200. PMID 14565954.
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