Misplaced Pages

STAT5B

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from STAT5b deficiency) Protein-coding gene in the species Homo sapiens

STAT5B
Identifiers
AliasesSTAT5B, STAT5, signal transducer and activator of transcription 5B, GHISID2
External IDsOMIM: 604260; MGI: 103035; HomoloGene: 55718; GeneCards: STAT5B; OMA:STAT5B - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for STAT5BGenomic location for STAT5B
Band17q21.2Start42,199,177 bp
End42,276,707 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for STAT5BGenomic location for STAT5B
Band11 D|11 63.63 cMStart100,671,557 bp
End100,741,550 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • body of uterus

  • left uterine tube

  • right ovary

  • left ovary

  • paraflocculus of cerebellum

  • beta cell

  • frontal pole

  • granulocyte

  • middle frontal gyrus
Top expressed in
  • medial head of gastrocnemius muscle

  • triceps brachii muscle

  • ankle

  • muscle of thigh

  • temporal muscle

  • vastus lateralis muscle

  • granulocyte

  • thymus

  • sternocleidomastoid muscle

  • seminal vesicula
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6777

20851

Ensembl

ENSG00000173757

ENSMUSG00000020919

UniProt

P51692

P42232

RefSeq (mRNA)

NM_012448

NM_001113563
NM_011489
NM_001362682

RefSeq (protein)

NP_036580

NP_001107035
NP_035619
NP_001349611

Location (UCSC)Chr 17: 42.2 – 42.28 MbChr 11: 100.67 – 100.74 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available.

Function

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.

Interactions

STAT5B has been shown to interact with:

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000173757Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020919Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883.
  6. "OrthoMaM phylogenetic marker: STAT5B coding sequence". Archived from the original on 2015-09-24. Retrieved 2010-02-17.
  7. "Entrez Gene: STAT5B signal transducer and activator of transcription 5B".
  8. Stöcklin E, Wissler M, Gouilleux F, Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid receptor" (PDF). Nature. 383 (6602): 726–8. Bibcode:1996Natur.383..726S. doi:10.1038/383726a0. PMID 8878484. S2CID 4356272.
  9. ^ Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene. 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382. S2CID 20789082.
  10. Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. 273 (20): 12567–75. doi:10.1074/jbc.273.20.12567. PMID 9575217.
  11. Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. 275 (1): 599–604. doi:10.1074/jbc.275.1.599. PMID 10617656.

Further reading

  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene. 285 (1–2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.
PDB gallery
  • 1y1u: Structure of unphosphorylated STAT5a 1y1u: Structure of unphosphorylated STAT5a
Cytokine receptor modulators
Chemokine
CSF
Erythropoietin
G-CSF (CSF3)
GM-CSF (CSF2)
M-CSF (CSF1)
SCF (c-Kit)
Thrombopoietin
Interferon
IFNAR (α/β, I)
IFNGR (γ, II)
IFNLR (λ, III)
  • See IL-28R (IFNLR) here instead.
Interleukin
TGFβ
TNF
Others
JAK
(inhibitors)
JAK1
JAK2
JAK3
TYK2
Others

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Stub icon

This article on a gene on human chromosome 17 is a stub. You can help Misplaced Pages by expanding it.

Categories: