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STK17A
Identifiers
Aliases	STK17A, DRAK1, serine/threonine kinase 17a
External IDs	OMIM: 604726; HomoloGene: 55846; GeneCards: STK17A; OMA:STK17A - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p13 Start 43,582,758 bp End 43,650,713 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node epithelium of nasopharynx granulocyte appendix blood bone marrow ganglionic eminence ventricular zone vena cava Achilles tendon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding Cellular component nucleus plasma membrane nuclear speck Biological process positive regulation of apoptotic process positive regulation of fibroblast apoptotic process protein phosphorylation intracellular signal transduction regulation of reactive oxygen species metabolic process phosphorylation apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9263 n/a Ensembl ENSG00000164543 n/a UniProt Q9UEE5 n/a RefSeq (mRNA) NM_004760 n/a RefSeq (protein) NP_004751 n/a Location (UCSC) Chr 7: 43.58 – 43.65 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164543 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Entrez Gene: Serine/threonine kinase 17a".
4. Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849. PMC 8096429. PMID 33941312.

Further reading

• Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, et al. (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
• Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
• Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, et al. (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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