Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.
This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.
Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.
References
- ^ ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 – Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.
- ^ "SURF4 Gene - Surfeit 4". Retrieved 8 June 2022.
- "Entrez Gene: SURF4 surfeit 4".
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