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SYNE3
Identifiers
Aliases	SYNE3, C14orf49, NET53, Nesp3, spectrin repeat containing nuclear envelope family member 3, C14orf139, KASH3, LINC00341, NCRNA00341
External IDs	OMIM: 610861; MGI: 2442408; HomoloGene: 17625; GeneCards: SYNE3; OMA:SYNE3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.13 Start 95,407,266 bp End 95,516,650 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 E Start 104,896,192 bp End 104,976,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii parietal pleura synovial membrane trabecular bone synovial joint skin of hip visceral pleura superficial temporal artery pericardium skin of thigh Top expressed in neural layer of retina granulocyte zygote lip embryo thymus endothelial cell of lymphatic vessel esophagus embryo secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding protein binding cytoskeletal protein binding Cellular component integral component of membrane rough endoplasmic reticulum nuclear outer membrane nuclear envelope membrane meiotic nuclear membrane microtubule tethering complex nucleus endoplasmic reticulum nuclear membrane cytoplasm Biological process establishment of protein localization to membrane cytoskeleton organization regulation of cell shape nuclear migration nucleus localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 161176 212073 Ensembl ENSG00000176438 ENSMUSG00000054150 UniProt Q6ZMZ3 Q4FZC9 RefSeq (mRNA) NM_024633 NM_152592 NM_001363692 NM_001384281 NM_001384282 NM_001384283 NM_001384284 NM_001042699 NM_172500 RefSeq (protein) NP_689805 NP_001350621 NP_001036164 NP_766088 NP_001390387 Location (UCSC) Chr 14: 95.41 – 95.52 Mb Chr 12: 104.9 – 104.98 Mb PubMed search
Wikidata
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Spectrin repeat containing nuclear envelope family member 3, or Nesprin-3, is a Nesprin-family protein that in humans is encoded by the SYNE3 gene. Nesprin-3 localizes to the outer nuclear membrane, where it is retained by SUN domain-containing proteins. The n-terminus of Nesprin-3 faces the cytoplasm and associates with the cytolinker protein Plectin.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000176438 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000054150 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Spectrin repeat containing nuclear envelope family member 3". Retrieved 2018-05-27.
6. Wilhelmsen K, Litjens SH, Kuikman I, Tshimbalanga N, Janssen H, van den Bout I, et al. (December 2005). "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin". The Journal of Cell Biology. 171 (5): 799–810. doi:10.1083/jcb.200506083. PMC 2171291. PMID 16330710.

Further reading

• Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, et al. (October 2008). "TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton". Journal of Cell Science. 121 (Pt 20): 3476–3486. doi:10.1242/jcs.029454. PMC 3539201. PMID 18827015.
• Morgan JT, Pfeiffer ER, Thirkill TL, Kumar P, Peng G, Fridolfsson HN, et al. (November 2011). "Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization". Molecular Biology of the Cell. 22 (22): 4324–4334. doi:10.1091/mbc.E11-04-0287. PMC 3216658. PMID 21937718.
• Liao M, Li B, Zhang S, Liu Q, Liao W, Xie W, Zhang Y (February 2017). "Relationship between LINC00341 expression and cancer prognosis". Oncotarget. 8 (9): 15283–15293. doi:10.18632/oncotarget.14843. PMC 5362486. PMID 28146429.

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