Safi al-Din (Arabic: صفي الدين) is an Arabic masculine given name and surname. It may also be spelled as Safi-ad-din, Safiuddin, Safieddine etc. The name is composed of two Arabic elements: Safi (صافي) meaning pure and Al-Din (الدین) religion. It may refer to:
- Safi al-Din al-Urmawi (c. 1216 – 1294), Persian musician and writer
- Safi al-Din al-Hindi (c. 1246–1315), Shafi'i-Ash'ari scholar
- Safi-ad-din Ardabili (1252–1334), eponym of the Safavid dynasty
- Safiuddin Ahmed (1922–2012), Bangladeshi painter
- Francois Safieddine, American poker player
- Hashem Safieddine (1964–2024), Lebanese Shia cleric and Hezbollah leader
See also
- Safiuddin Sarker Academy and College, Bangladesh
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