Saira may refer to:
People
- Nikolas Saira (born 1999), Finnish footballer
- Saira Banu (born 1944), Indian film actress
- Saira Elizabeth Luiza Shah (1900–1960), Scottish writer who wrote under the pen name Morag Murray Abdullah
- Saira Shah (born 1964), author, reporter and documentary filmmaker
- Saira Khan (born 1970), runner-up on the first series of The Apprentice (Great Britain)
- Saira Mohan (born 1978), Canadian fashion model of Indian, French and Irish descent
- Saira Choudhry (born 1988), British actress
- Saira Blair (born 1996), American politician
- Saira Khan (actress), Pakistani actress
- Saira Peter, First Pakistani Opera singer.
- Saira Wasim (born 1975), Pakistani artist
Other
- Cololabis saira, the scientific name of the Pacific saury fish
- Saira Batra, a character on the television series General Hospital: Night Shift
- Saira (film), a 2005 Malayalam Language Indian film starring Navya Nair and Nedumudi Venu
- Saira (video game), a computer game developed by Nifflas in 2009
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