Samadov (Azerbaijani: Səmədov, Russian: Самадов) is an Asian masculine surname, its feminine counterpart is Samadova. Notable people with the surname include:
- Abdujalil Samadov (1949–2004), prime minister of Tajikistan
- Alibay Samadov (born 1982), Russian-born Azerbaijani weightlifter
- Fazila Samadova (1929–2020), Azerbaijani scientist
- Ibragim Samadov (born 1968), Soviet weightlifter
- Javid Samadov (born 1987), Azerbaijani opera singer
- Ogtay Samadov (born 1952), Azerbaijani scientist
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