Samuel Mitchell may refer to:
- Samuel Mitchell (Western Australian politician) (1838–1912), Western Australian politician
- Samuel Mitchell (VC) (1841–1894), Victoria Cross recipient
- Samuel Alfred Mitchell (1874–1960), Canadian astronomer
- Samuel Augustus Mitchell (1790–1868), American geographer
- Samuel Brown Wylie Mitchell (1828–1879), founder of Phi Kappa Sigma fraternity
- Samuel James Mitchell (1852–1926), South Australian politician and judge
- Samuel N. Mitchell (1846–1905), American lyricist
See also
- Samuel L. Mitchill (1764–1831), American doctor and politician
- Sam Mitchell (disambiguation)
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