San Juan Nepomuceno is the Spanish name for Saint John of Nepomuk
- San Juan Nepomuceno (1765), a 74-gun Spanish ship of the line that took part in the Battle of Trafalgar, under the command of Brigadier Don Cosme Damian Churruca
- San Juan Nepomuceno, Bolívar, a municipality in Bolívar department of Colombia
- San Juan Nepomuceno, Mexico, a mining area in San Joaquín Municipality, Querétaro
- San Juan Nepomuceno, Paraguay
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