Sanctum may refer to:
Arts and entertainment
- Sanctum (band), a Swedish electronic and industrial music band
- Sanctum (film), a 2011 action-thriller film
- Sanctum (1998 video game), a digital collectible card game
- Sanctum (2011 video game), a first-person shooter tower defense video game
Other uses
- Sanctum (company), an American information technology company focused on application security
See also
- Sanctum sanctorum, a Latin phrase meaning "Holy of Holies"
- Sanctum Sanctorum (Marvel Comics), a fictional building in the Marvel Universe
- Garbhagriha, the innermost sanctuary of Hindu, Jain, and Buddhist temples
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