Sant'Egidio may refer to:
- St. Giles (640?–720?)
- Community of Sant'Egidio, an international Christian lay community
- Sant'Egidio, Rome (Trastevere), the church from which the community of Sant'Egidio takes its name
- Sant'Egidio (Mantua), a church in Mantua, Italy
Placenames
- Sant'Egidio alla Vibrata, a comune in the province of Teramo, Abruzzo
- Sant'Egidio del Monte Albino, a comune in the province of Salerno, Campania
- Sant'Egidio, a hamlet of the comune of Ferrara
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