Santee may refer to:
People
- Santee Dakota, a subgroup of the Dakota people, of the U.S. Great Plains
- Santee (South Carolina), a Native American people of South Carolina
Places
- Lake Santee, Indiana, a reservoir and census-designated place
- Santee, California
- Santee (Corbin, Virginia), a historic plantation home
- Santee Indian Reservation in Nebraska
- Santee, Nebraska
- Santee, South Carolina
- Santee River in South Carolina
Other uses
- Santee (surname)
- Santee Education Complex, Los Angeles, California
- Santee (film), a 1973 western starring Glenn Ford
- Santee (plumbing), a tee joint in a sanitation line
- USS Santee, multiple ships of the United States Navy
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