Santo is a masculine given name which may refer to:
People
- Santo Biasatti (born 1943), Argentine journalist
- Santo Cilauro (born 1961), Australian comedian, actor, and television producer
- Santo Condorelli (born 1995), Italian swimmer
- Santo Farina, of the rock and roll duo Santo & Johnny
- Santo Jeger (1898–1953), British politician
- Santo Loquasto (born 1944), American production, set and costume designer
- Santo Mazzarino (1916–1987), Italian historian
- Santo Santoro (born 1956), Australian politician
- Santo Stephens (born 1969), American football player
- Santo Trafficante Jr. (1914–1987), American Mafia boss, head of the Trafficante crime family
- Santo Trafficante Sr. (1886–1954), Sicilian-born mobster, father of the above
- Santo Versace (born 1944), Italian businessman and politician
Fictional People
- Santo Vaccarro (Rockslide), a hero appearing in X-Men comics
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