Schlein is a German- and Yiddish-language surname. Notable people with the surname include:
- Elly Schlein (born 1985), Italian politician
- Benjamin Schlein (born 1975), Italian mathematician
- Michael Schlein (born 1961), American entrepreneur, president and CEO of Accion
- Miriam Schlein (1926–2004), American author
- Rory Schlein (born 1984), Australian international speedway rider
- Ted Schlein, general partner of Kleiner Perkins Caufield & Byers
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