Sekhmet is an Egyptian goddess.
Sekhmet may also refer to:
- 5381 Sekhmet, an asteroid
- Sekhmet (Re:Zero), a character in the light novel series Re:Zero − Starting Life in Another World
- Sekhmet (Ronin Warriors), a character from the Japanese anime series
- Sekhmet (Marvel Comics)
- Sekhmet, one of the 17 Titans in the film, Godzilla: King of the Monsters.
- A Vasudan heavy bomber in the game Freespace 2
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