The Senio is a river in Italy. Senio may also refer to:
People
- Senio Kelemete (born 1990), American football player
- Senio Toleafoa (born 1993), Australian rugby union player
- John Senio (born 1982), Samoan rugby union player
- Kevin Senio (born 1978), New Zealand rugby union player
Other uses
- Palazzuolo sul Senio, commune in Italy
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