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In Indiana, Sarah Jo Pender, a student, is sent to prison after her two roommates were murdered by her boyfriend Rick. She claims her innocence. After one of her appeals is denied, she escapes with the help of Prison Guard Scott Spitler and her friend Jamie Long. The Marshall Sean Harlan unsuccessfully pursues her and has to rely on the help of TV show America's Most Wanted. After Pender is captured by local police officers, he picks her up and drives her back to prison.