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Sibiromycin

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Sibiromycin
Names
IUPAC name (6R,6aS)-2-oxy-4,6-dihydroxy-3-methyl-8--5,6,6a,7-tetrahydropyrrolobenzodiazepin-11-one
Other names Sybiromycin
Identifiers
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Properties
Chemical formula C24H33N3O7
Molar mass 475.542 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Sibiromycin is an antitumor antibiotic with the molecular formula C24H33N3O7 which is produced by the bacterium Streptosporangium sibiricum. Sibiromycin is a pyrrolobenzodiazepine.

References

  1. ^ "Sibiromycin". Pubchem.ncbi.NLM.nih.gov.
  2. Gause, G. F. (1975). "Sibiromycin". Mechanism of Action of Antimicrobial and Antitumor Agents. pp. 269–273. doi:10.1007/978-3-642-46304-4_17. ISBN 978-3-642-46306-8.
  3. Li, Wei; Khullar, Ankush; Chou, ShenChieh; Sacramo, Ashley; Gerratana, Barbara (May 2009). "Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic". Applied and Environmental Microbiology. 75 (9): 2869–2878. Bibcode:2009ApEnM..75.2869L. doi:10.1128/AEM.02326-08. PMC 2681668. PMID 19270142.
  4. Rhoads, Robert E. (6 December 2012). Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970. Springer Science & Business Media. p. 33. ISBN 978-3-642-65141-0.
  5. Antibiotics and Chemotherapy. S. Karger. 1980. p. 105. ISBN 978-3-8055-2830-6.
  6. Rahman, Khondaker Miraz; Thurston, David E. (6 September 2018). Small-Molecule Transcription Factor Inhibitors in Oncology. Royal Society of Chemistry. p. 87. ISBN 978-1-78262-145-4.

Further reading

  • Kersten, H.; Kersten, W. (11 November 2013). Inhibitors of Nucleic Acid Synthesis: Biophysical and Biochemical Aspects. Springer Science & Business Media. p. 19. ISBN 978-3-642-80855-5.
  • Corcoran, John W. (6 December 2012). Biosynthesis. Springer Science & Business Media. p. 277. ISBN 978-3-642-67724-3.
  • Comprehensive Natural Products III. Elsevier. 22 July 2020. p. 412. ISBN 978-0-08-102691-5.
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