Sisam is the Ottoman Turkish name for the island of Samos, Greece.
Sisam may also refer to:
- Ainu word for a Japanese person
- Sisam hypothesis on royal genealogies
- Syresham, UK village from which the English name Sisam is derived
People with the surname Sisam
- Charles Herschel Sisam (1879–1964), an American mathematician
- Kenneth Sisam (1887-1971), a New Zealand academic and publisher
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