Sixsmith is an occupational surname formerly used by someone who made sickles. Notable people with the surname include:
- Arthur Sixsmith (1880–1969), Canadian ice hockey rover and businessman
- Ed Sixsmith (1863–1926), American baseball catcher
- Eric Sixsmith (1904–1986), British Army general
- Garnet Sixsmith (1885–1967), Canadian ice hockey player
- Jane Sixsmith (born 1967), British field hockey player, Olympic bronze medallist
- Martin Sixsmith (born 1954), British author, journalist and radio/television presenter
- Paul Sixsmith (born 1971), Maltese international footballer
- Rufus Sixsmith, character in 2012 film Cloud Atlas
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