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Small Cajal body specific RNA 24

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Small Cajal body specific RNA 24
Predicted secondary structure and sequence conservation of SCARNA24
Identifiers
SymbolSCARNA24
Alt. SymbolssnoACA12
RfamRF00422
Other data
RNA typeGene; snRNA; snoRNA; scaRNA
Domain(s)Eukaryota
GOGO:0006396 GO:0015030 GO:0005730
SOSO:0000275
PDB structuresPDBe

Small Cajal body specific RNA 24 (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

ACA12 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1 protein. ACA12 is predicted to guide the pseudouridylation of residue U40 of the spliceosomal U6 snRNA.

References

  1. Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–56. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
  2. ^ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  3. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.

External links

Small Cajal body-specific RNA
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