Misplaced Pages

IgA pemphigus
Schematic of immunoglobulin A dimer showing H-chain (blue), L-chain (red), J-chain (magenta) and secretory component (yellow).
Specialty	Dermatology

IgA pemphigus is a subtype of pemphigus with two distinct forms:

• Subcorneal pustular dermatosis (also known as Sneddon–Wilkinson disease and pustulosis subcornealis) is skin condition that is a rare, chronic, recurrent, pustular eruption characterized histopathologically by subcorneal pustules that contain abundant neutrophils. This is distinct from and not to be confused with subcorneal pustular dermatosis type of IgA pemphigus. Sneddon's syndrome, also known as Ehrmann-Sneddon syndrome, is also a different syndrome.
• Intraepidermal neutrophilic IgA dermatosis is characterized histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis.

History

Early descriptions were made by Darrell Wilkinson, a British dermatologist.

See also

• Pemphigus
• List of target antigens in pemphigus
• List of conditions caused by problems with junctional proteins
• List of immunofluorescence findings for autoimmune bullous conditions

References

1. RESERVED, INSERM US14 -- ALL RIGHTS. "Orphanet: Subcorneal pustular dermatosis". www.orpha.net. Retrieved 8 March 2017.{{cite web}}: CS1 maint: numeric names: authors list (link)
2. Irwin M. Freedberg; et al., eds. (2003). Fitzpatrick's dermatology in general medicine (6th ed.). New York, NY : McGraw-Hill. p. 625. ISBN 978-0-07-138076-8.
3. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
4. Berlit, Peter. "Sneddon's Syndrome". Orphanet.
5. "Munks Roll Details for Peter Edward Darrell Sheldon Wilkinson". munksroll.rcplondon.ac.uk. Archived from the original on 2017-11-10. Retrieved 2017-11-10.

External links

• v
• t
• e

• Chronic blistering cutaneous conditions
• Genodermatoses stubs