Misplaced Pages

Solute carrier organic anion transporter family member 1A2

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
SLCO1A2
Identifiers
AliasesSLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3, solute carrier organic anion transporter family member 1A2
External IDsOMIM: 602883; MGI: 1351865; HomoloGene: 56603; GeneCards: SLCO1A2; OMA:SLCO1A2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for SLCO1A2Genomic location for SLCO1A2
Band12p12.1Start21,264,600 bp
End21,419,594 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for SLCO1A2Genomic location for SLCO1A2
Band6|6 G2Start142,179,953 bp
End142,268,707 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • corpus callosum

  • Amygdala

  • optic nerve

  • putamen

  • substantia nigra

  • Hypothalamus

  • caudate nucleus

  • hippocampus proper

  • Brodmann area 9
Top expressed in
  • seminal vesicula

  • vestibular membrane of cochlear duct

  • stria vascularis

  • vestibular sensory epithelium

  • salivary gland

  • choroid plexus

  • Epithelium of choroid plexus

  • olfactory epithelium

  • submandibular gland

  • lacrimal gland
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6579

108096

Ensembl

ENSG00000084453

ENSMUSG00000063975

UniProt

P46721

Q91YY5

RefSeq (mRNA)

NM_005075
NM_021094
NM_134431

NM_001267707
NM_130861

RefSeq (protein)

NP_066580
NP_602307

NP_001254636
NP_570931

Location (UCSC)Chr 12: 21.26 – 21.42 MbChr 6: 142.18 – 142.27 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000084453 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000063975 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
  6. ^ "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders
Stub icon

This membrane protein–related article is a stub. You can help Misplaced Pages by expanding it.

Categories: