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Solute carrier organic anion transporter family member 1B3

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Protein-coding gene in the species Homo sapiens
SLCO1B3
Identifiers
AliasesSLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDsOMIM: 605495; MGI: 1351899; HomoloGene: 75119; GeneCards: SLCO1B3; OMA:SLCO1B3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for SLCO1B3Genomic location for SLCO1B3
Band12p12.2Start20,810,702 bp
End20,916,911 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for SLCO1B3Genomic location for SLCO1B3
Band6 G2|6 72.57 cMStart141,575,244 bp
End141,632,372 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • testicle

  • olfactory zone of nasal mucosa

  • Epithelium of choroid plexus

  • gonad

  • nasal epithelium

  • buccal mucosa cell

  • tibial nerve

  • canal of the cervix

  • gallbladder
Top expressed in
  • left lobe of liver

  • embryo

  • sexually immature organism

  • medial head of gastrocnemius muscle

  • primary visual cortex

  • proximal tubule

  • jejunum

  • thoracic diaphragm

  • pancreas

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

28234

28253

Ensembl

ENSG00000111700

ENSMUSG00000030236

UniProt

Q9NPD5

Q9JJL3

RefSeq (mRNA)

NM_019844
NM_001349920

NM_020495
NM_178235

RefSeq (protein)

NP_062818
NP_001336849

NP_065241

Location (UCSC)Chr 12: 20.81 – 20.92 MbChr 6: 141.58 – 141.63 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression. Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.

Substrates

Small molecules that are transported by SLCO1B3 include:

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000111700Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030236Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  6. Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (June 2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758.
  7. ^ Heather Pressler; Tristan M. Sissung; David Venzon; Douglas K. Price; William D. Figg (May 2011). "Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression". PLOS ONE. 6 (5): e20372. Bibcode:2011PLoSO...620372P. doi:10.1371/journal.pone.0020372. PMC 3098289. PMID 21625523.
  8. Hagenbuch B, Gui C (July 2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430. S2CID 85868712.

Further reading

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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