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Solute carrier organic anion transporter family member 2A1

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Protein-coding gene in the species Homo sapiens
SLCO2A1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3MRR

Identifiers
AliasesSLCO2A1, MATR1, OATP2A1, PGT, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1, PHOAD
External IDsOMIM: 601460; MGI: 1346021; HomoloGene: 38077; GeneCards: SLCO2A1; OMA:SLCO2A1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for SLCO2A1Genomic location for SLCO2A1
Band3q22.1-q22.2Start133,932,701 bp
End134,052,184 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for SLCO2A1Genomic location for SLCO2A1
Band9 F1|9 54.72 cMStart102,865,911 bp
End102,973,201 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lung

  • upper lobe of left lung

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • lower lobe of lung

  • seminal vesicula

  • cardia

  • left uterine tube

  • gastric mucosa

  • body of uterus
Top expressed in
  • decidua

  • right lung

  • gastrula

  • endothelial cell of lymphatic vessel

  • pyloric antrum

  • left lung

  • right lung lobe

  • left lung lobe

  • epithelium of stomach

  • epithelium of small intestine
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6578

24059

Ensembl

ENSG00000174640

ENSMUSG00000032548

UniProt

Q92959

Q9EPT5

RefSeq (mRNA)

NM_005630

NM_033314

RefSeq (protein)

NP_005621

NP_201571

Location (UCSC)Chr 3: 133.93 – 134.05 MbChr 9: 102.87 – 102.97 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy, specific form of chronic enteropathy.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000174640Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032548Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30.
  6. Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (January 2012). "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy". American Journal of Human Genetics. 90 (1): 125–32. doi:10.1016/j.ajhg.2011.11.019. PMC 3257902. PMID 22197487.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q92959 (Solute carrier organic anion transporter family member 2A1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
(1):
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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