Sophia Smith may refer to:
- Sophia Smith (soccer, born 2000), American soccer player
- Sophia Smith (soccer, born 1978), American-Greek former soccer player
- Sophia Smith (Smith College) (1796–1870), founder of Smith College
- Sophia Smith Collection, repository of manuscripts, photographs, periodicals and other primary sources in women's history
- Sofia Smith (influencer) (born 2006), social media personality
See also
- Sophia Smith Galer (born 1994), British journalist
- Sofia Tekela-Smith (born 1960), New Zealand artist
- Sophie Smith (born 1986), Australian water polo player
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