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Southern multimammate mouse
Conservation status
Least Concern  (IUCN 3.1)
Scientific classification
Domain:	Eukaryota
Kingdom:	Animalia
Phylum:	Chordata
Class:	Mammalia
Order:	Rodentia
Family:	Muridae
Genus:	Mastomys
Species:	M. coucha
Binomial name
Mastomys coucha (Smith, 1834)

The southern multimammate mouse or southern African mastomys (Mastomys coucha) is a species of rodent in the family Muridae which is endemic to southern Africa (Angola, Botswana, Lesotho, Mozambique, Namibia, South Africa, and Zimbabwe). It is called a multimammate mouse because it can have 8 to 12 pairs of mammae (milk producing glands), in comparison other mouse species only have 5 pairs.

Diet and habitat

The southern multimammate mouse is a nocturnal species considered to be an ecological generalist, and is found in a broad spectrum of natural habitats. These habitats include open grassland (dry and moist), shrubland (dry and moist), and semidesert karoo land. M. coucha is generally thought to have three main disjunct geographical populations, but recent studies have shown extensive haplotype sharing between the three populations.

M. coucha is an opportunist omnivore. Its diet consists of a variety of plant and animal resources, including cannibalism when under severe resource limitations. Due to this generalist behavior M. coucha is often found in disturbed environments (drought, fire, overgrazing, etc.) and its presence could be an indicator of an ecosystem’s integrity.

Identification

M. coucha is sympatric with M. natalensis and the two species cannot be distinguished by superficial appearance alone. M. coucha and M. natalensis can be definitively identified by karyotyping (they have different numbers of chromosomes) or DNA sequencing. However, on closer analysis they do have anatomical (cranial, dental and phallic morphology) and physiological (hemoglobin pattern and pheromones) differences.

Many academic labs and publicly available animals were derived from a colony originally misidentified as M. natalensis.

Research

M. coucha has been used frequently in medical research. Unlike the common murine research model, M. coucha has been maintained as an outbred line so it has maintained the genetic heterogeneity necessary for many studies involving immune response. M. coucha also has a naturally occurring papillomavirus that mimics the infection cycle and symptoms seen in humans with HPVs. These two traits have made it a good model to study vaccines against HPV infections.

Similarly, unlike the common murine research model, M. coucha can support the complete lifecycle of B. malayi, a parasite that causes lymphatic filariasis. This has made it a key tool in discovering new drugs and vaccines to fight an infection that affects an estimated 130 million people.

Domestication

The southern multimammate rat is currently being bred in the US and Canada as a pet, and as a replacement food source for reptiles, replacing the brown rat as a viable food source for picky eaters. It is also recognized as one of the natural food sources for ball pythons. They are also being used for stomach cancer research, among other ailments. Europeans have begun breeding them for companion animal use, namely in Germany and England. This trend is also catching, slowly, in the US and Canada.

Only recently has it been introduced to the pet trade, and is more often kept as a feeder rodent for snakes than as a pet.

References

1. Cassola, F. (2016). "Mastomys coucha". IUCN Red List of Threatened Species. 2016: e.T12865A22425161. doi:10.2305/IUCN.UK.2016-2.RLTS.T12865A22425161.en. Retrieved 15 November 2021.
2. Sands, Arthur F.; Matthee, Sonja; Mfune, John K. E.; Matthee, Conrad A. (2015-01-01). "The influence of life history and climate driven diversification on the mtDNA phylogeographic structures of two southern African Mastomys species (Rodentia: Muridae: Murinae)". Biological Journal of the Linnean Society. 114 (1): 58–68. doi:10.1111/bij.12397. ISSN 1095-8312.
3. Codron, Jacqueline; Duffy, Kevin J.; Avenant, Nico L.; Sponheimer, Matt; Leichliter, Jennifer; Paine, Oliver; Sandberg, Paul; Codron, Daryl (2015-06-01). "Stable isotope evidence for trophic niche partitioning in a South African savanna rodent community". Current Zoology. 61 (3): 397–411. doi:10.1093/czoolo/61.3.397. ISSN 1674-5507.
4. Avenant, Nico (2011-12-21). "The potential utility of rodents and other small mammals as indicators of ecosystem 'integrity' of South African grasslands". Wildlife Research. 38 (7): 626. doi:10.1071/wr10223. ISSN 1448-5494.
5. Kruppa, T. F.; Iglauer, F; Ihnen, E; Miller, K; Kunstyr, I (1990). "Mastomys natalensis or Mastomys coucha. Correct species designation in animal experiments". Tropical Medicine and Parasitology. 41 (2): 219–20. PMID 2382103.
6. Vinzón, Sabrina E.; Braspenning-Wesch, Ilona; Müller, Martin; Geissler, Edward K.; Nindl, Ingo; Gröne, Hermann-Josef; Schäfer, Kai; Rösl, Frank (2014-02-20). "Protective Vaccination against Papillomavirus-Induced Skin Tumors under Immunocompetent and Immunosuppressive Conditions: A Preclinical Study Using a Natural Outbred Animal Model". PLOS Pathogens. 10 (2): e1003924. doi:10.1371/journal.ppat.1003924. ISSN 1553-7374. PMC 3930562. PMID 24586150.
7. Kushwaha, Susheela; Singh, Prashant Kumar; Rana, Ajay Kumar; Misra-Bhattacharya, Shailja (2013-08-28). "Immunization of Mastomys coucha with Brugia malayi Recombinant Trehalose-6-Phosphate Phosphatase Results in Significant Protection against Homologous Challenge Infection". PLOS ONE. 8 (8): e72585. Bibcode:2013PLoSO...872585K. doi:10.1371/journal.pone.0072585. ISSN 1932-6203. PMC 3755969. PMID 24015262.
8. Kalani, Komal; Kushwaha, Vikas; Sharma, Pooja; Verma, Richa; Srivastava, Mukesh; Khan, Feroz; Murthy, P. K.; Srivastava, Santosh Kumar (2014-11-06). "In Vitro, In Silico and In Vivo Studies of Ursolic Acid as an Anti-Filarial Agent". PLOS ONE. 9 (11): e111244. Bibcode:2014PLoSO...9k1244K. doi:10.1371/journal.pone.0111244. ISSN 1932-6203. PMC 4222910. PMID 25375886.

Further reading

• Musser, Guy G.; Carleton, Michael D. (2006). "Superfamily Muroidea". In Wilson, Don E.; Reeder, DeeAnn M. (eds.). Mammal Species of the World: A Taxonomic and Geographic Reference. Baltimore: Johns Hopkins University Press. pp. 894–1531. ISBN 978-0-8018-8221-0.
• Haag, Andreas; Wayss, Klaus; Rommelaere, Jean; Cornelis, Jan (2000). "Experimentally induced infection with autonomous parvoviruses, minute virus of mice and H-1, in the African multimammate mouse (Mastomys coucha)". Comparative Medicine. 50 (6): 613–21. PMID 11200567.
• Vinzón, Sabrina E.; Braspenning-Wesch, Ilona; Müller, Martin; Geissler, Edward K.; Nindl, Ingo; Gröne, Hermann-Josef; Schäfer, Kai; Rösl, Frank (2014). "Protective Vaccination against Papillomavirus-Induced Skin Tumors under Immunocompetent and Immunosuppressive Conditions: A Preclinical Study Using a Natural Outbred Animal Model". PLOS Pathogens. 10 (2): e1003924. doi:10.1371/journal.ppat.1003924. PMC 3930562. PMID 24586150.
• Lütkefels, Elke Maria Hermine (2003). Licht- und elektronenmikroskopische Untersuchungen von Lunge und Pleura der mit Litomosoides sigmodontis infizierten Mastomys coucha [Histopathological and electron microscopical studies of lung and pleura in Litomosoides sigmodontis infected Mastomys coucha] (Dissertation) (in German). University of Giessen.

• IUCN Red List least concern species
• Mastomys
• Rodents of Africa
• Mammals described in 1834