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Spheroidene monooxygenase (EC 1.14.15.9, CrtA, acyclic carotenoid 2-ketolase, spirilloxantin monooxygenase, 2-oxo-spirilloxanthin monooxygenase) is an enzyme with systematic name spheroidene, reduced-ferredoxin:oxygen oxidoreductase (spheroiden-2-one-forming). This enzyme catalyses the following chemical reaction

spheroidene + reduced ferredoxin + O₂ ${\displaystyle \rightleftharpoons }$ spheroiden-2-one + oxidized ferredoxin + H₂O

spirilloxantin + reduced ferredoxin + O₂ ${\displaystyle \rightleftharpoons }$ 2-oxospirilloxanthin + oxidized ferredoxin + H₂O

2'-oxospirilloxanthin + reduced ferredoxin + O₂ ${\displaystyle \rightleftharpoons }$ 2,2'-dioxospirilloxanthin + oxidized ferredoxin + H₂O

The enzyme is involved in spheroidenone biosynthesis and in 2,2'-dioxospirilloxanthin biosynthesis.

References

1. Lee PC, Holtzapple E, Schmidt-Dannert C (November 2010). "Novel activity of Rhodobacter sphaeroides spheroidene monooxygenase CrtA expressed in Escherichia coli". Applied and Environmental Microbiology. 76 (21): 7328–31. doi:10.1128/AEM.01606-10. PMC 2976243. PMID 20851979.
2. Gerjets T, Steiger S, Sandmann G (February 2009). "Catalytic properties of the expressed acyclic carotenoid 2-ketolases from Rhodobacter capsulatus and Rubrivivax gelatinosus". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791 (2): 125–31. doi:10.1016/j.bbalip.2008.12.006. PMID 19136077.

External links

• Spheroidene+monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.14.15