Spiliotopoulos (Greek: Σπηλιωτόπουλος) is a Greek surname. Notable people with the surname include:
- Aris Spiliotopoulos (born 1966), Greek politician
- Evan Spiliotopoulos, Greek-American screenwriter
- Panagiotis Spiliotopoulos (1891–1962), Greek army officer
- Spilios Spiliotopoulos (born 1941), Greek politician
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