Spruce Run may refer to:
- Spruce Run (Delaware County, Ohio)
- Spruce Run (Buffalo Creek tributary), in Union County, Pennsylvania
- Spruce Run (Little Fishing Creek tributary), in Columbia County, Pennsylvania
- Spruce Run (Raritan River tributary), in Hunterdon County, New Jersey
- Spruce Run, New Jersey, in Hunterdon County, New Jersey
- Spruce Run Recreation Area, in Hunterdon County, New Jersey
Topics referred to by the same termThis disambiguation page lists articles about distinct geographical locations with the same name.If an internal link led you here, you may wish to change the link to point directly to the intended article. Category: