St Mary's Island may refer to:
Places
- England
- St Mary's Island, Kent, in Medway
- St Mary's Island, River Thames, in the county of Berkshire
- St Mary's Island (Tyne and Wear), in the metropolitan county of Tyne and Wear
- St Mary's, Isles of Scilly, in the county of Cornwall
- India
- St. Mary's Islands, in the state of Karnataka
- Isle of Man
- St Mary's Isle, Douglas Bay
- Madagascar
- Γle Sainte-Marie, also known as St Mary's Island in English, in the region of Analanjirofo
- The Gambia
- Another name for Banjul Island, in Banjul division
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