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Streptomyces cattleya

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Species of bacterium

Streptomyces cattleya
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Actinomycetota
Class: Actinomycetia
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: S. cattleya
Binomial name
Streptomyces cattleya
Noble et al. 1978

Streptomyces cattleya is a Gram-positive bacterium which makes cephamycin, penicillin and thienamycin. The bacterium expresses a fluorinase enzyme, and the organism has been used to understand the biosynthesis of fluoroacetate and the antibacterial 4-fluoro-L-threonine. The γ-Glu-βes pathway to biosynthesis of non-traditional amino acids β-ethynylserine (βes) and L-propargylglycine (Pra) was first characterized in this species.

The genome, which was sequenced in 2011, contains one chromosome with 6,283,062 base pairs and one megaplasmid with 1,809,491 bp, with an overall guanine-cytosine content of 73%.

References

  1. Bodner, MJ; Li, R; Phelan, RM; Freeman, MF; Moshos, KA; Lloyd, EP; Townsend, CA (Sep 19, 2011). "Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis". ChemBioChem. 12 (14): 2159–65. doi:10.1002/cbic.201100366. PMC 3281309. PMID 21913298.
  2. Kahan, JS; Kahan, FM; Goegelman, R; Currie, SA; Jackson, M; Stapley, EO; Miller, TW; Miller, AK; Hendlin, D; Mochales, S; Hernandez, S; Woodruff, HB; Birnbaum, J (Jan 1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". The Journal of Antibiotics. 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
  3. Kahan JS, Kahan FM, Goegelman R, et al. (1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". J. Antibiot. 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
  4. O'Hagan, David; Schaffrath, Christoph; Cobb, Steven L.; Hamilton, John T. G.; Murphy, Cormac D. (March 2002). "Biochemistry: Biosynthesis of an organofluorine molecule". Nature. 416 (6878): 279. Bibcode:2002Natur.416..279O. doi:10.1038/416279a. PMID 11907567. S2CID 4415511.
  5. Zhao, C; Li, P; Deng, Z; Ou, HY; McGlinchey, RP; O'Hagan, D (Oct 2012). "Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants". Bioorganic Chemistry. 44: 1–7. doi:10.1016/j.bioorg.2012.06.002. PMID 22858315.
  6. Reid, KA; Hamilton, JT; Bowden, RD; O'Hagan, D; Dasaradhi, L; Amin, MR; Harper, DB (Jun 1995). "Biosynthesis of fluorinated secondary metabolites by Streptomyces cattleya". Microbiology. 141 (6): 1385–93. doi:10.1099/13500872-141-6-1385. PMID 7670640.
  7. Kuehnel, Karin (May 2019). "A bacterial treasure trove". Nature Methods (Paper). 16 (5): 360. doi:10.1038/s41592-019-0411-1. PMID 31040424.(subscription required)
  8. Barbe, V; Bouzon, M; Mangenot, S; Badet, B; Poulain, J; Segurens, B; Vallenet, D; Marlière, P; Weissenbach, J (Sep 2011). "Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites". Journal of Bacteriology. 193 (18): 5055–6. doi:10.1128/JB.05583-11. PMC 3165681. PMID 21868806.
Taxon identifiers
Streptomyces cattleya


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