Stromelysin 2

Identifiers

Databases

PDB structures

Stromelysin 2 (EC 3.4.24.22, matrix metalloproteinase 10, transin 2, proteoglycanase 2) is an enzyme. This enzyme catalyses the following chemical reaction

Similar to stromelysin 1, but action on collagen types III, IV and V is weak

This enzyme belongs to the peptidase family M10 (interstitial collagenase family).

References

Breathnach R, Matrisian LM, Gesnel MC, Staub A, Leroy P (February 1987). "Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene". Nucleic Acids Research. 15 (3): 1139–51. doi:10.1093/nar/15.3.1139. PMC 340513. PMID 3547333.
Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (July 1988). "The collagenase gene family in humans consists of at least four members". The Biochemical Journal. 253 (1): 187–92. doi:10.1042/bj2530187. PMC 1149273. PMID 2844164.
Nicholson R, Murphy G, Breathnach R (June 1989). "Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases". Biochemistry. 28 (12): 5195–203. doi:10.1021/bi00438a042. PMID 2548603.

Stromelysin+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)