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Sumatriptan/naproxen

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Pharmaceutical product

Pharmaceutical compound
Sumatriptan/naproxen
Combination of
SumatriptanTriptan
NaproxenNonsteroidal anti-inflammatory drug (NSAID)
Clinical data
Trade namesTreximet, Suvexx, others
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
KEGG

Sumatriptan/naproxen, sold under the brand name Treximet among others, is a fixed-dose combination medication used to treat migraines. It is taken by mouth. It contains sumatriptan, as the succinate, a serotonin 5-hydroxytryptamine (5-HT) 1b/1d receptor agonist (triptan); and naproxen as the sodium salt, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs).

Medical uses

Sumatriptan/naproxen is indicated for the acute treatment of migraine with or without aura in people twelve years of age and older.

A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.

Side effects

Some of the listed side effects include dizziness, nausea, sleepiness, dry mouth, pain in neck, throat or jaw, numbness or tingling.

References

  1. "Regulatory Decision Summary - Suvexx". Health Canada. 23 October 2014. Retrieved 7 June 2022.
  2. ^ "Treximet- sumatriptan succinate and naproxen sodium tablet, film coated". DailyMed. 14 April 2022. Retrieved 7 June 2022.
  3. Law S, Derry S, Moore RA (April 2016). "Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults". The Cochrane Database of Systematic Reviews. 4 (4): CD008541. doi:10.1002/14651858.CD008541.pub3. PMC 6485397. PMID 27096438.
  4. "Treximet". Drugs.com.

External links

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