Main article: Swimming at the 2010 South American Games
The Women's 400m freestyle event at the 2010 South American Games was held on March 26, with the heats at 10:23 and the Final at 18:11.
Medalists
| Gold | Silver | Bronze |
Joanna Maranhão Brazil
|
Kristel Kobrich Chile
|
Cecilia Biagioli Argentina
|
Records
| Standing records prior to the 2010 South American Games | ||||
|---|---|---|---|---|
| World record |  Federica Pellegrini (ITA)
|
3:59.15 | Rome, Italy | 26 July 2009 |
| Competition Record | Cecilia Biagioli (ARG)
|
4:13.63 | Buenos Aires, Argentina | 15 November 2006 |
| South American record | Cecilia Biagioli (ARG)
|
4:10.16 | Rome, Italy | 26 July 2009 |
Results
Heats
| Rank | Heat | Lane | Athlete | Result | Notes |
|---|---|---|---|---|---|
| 1 | 2 | 5 | Kristel Kobrich (CHI)
|
4:26.78 | Q |
| 2 | 1 | 5 | Joanna Maranhão (BRA)
|
4:27.50 | Q |
| 3 | 1 | 4 | Cecilia Biagioli (ARG)
|
4:27.59 | Q |
| 4 | 2 | 3 |  Yanel Pinto (VEN)
|
4:28.57 | Q |
| 5 | 1 | 3 | Sarah Correa (BRA)
|
4:30.32 | Q |
| 6 | 1 | 6 | Darneyis Orozco (VEN)
|
4:30.92 | Q |
| 7 | 2 | 6 |  Nicole Maria Gilbert (ECU)
|
4:30.99 | Q |
| 8 | 2 | 2 |  Andrea del Rosario Rodriguez (PER)
|
4:31.70 | Q |
| 9 | 2 | 1 |  Isabela Acuña (COL)
|
4:33.14 | |
| 10 | 2 | 7 | Maria Alejandra Perez (PER)
|
4:34.54 | |
| 11 | 1 | 7 | Samantha Salinas (ECU)
|
4:35.08 | |
| 12 | 1 | 1 | Mariana Ramirez (CHI)
|
4:38.48 | |
| 13 | 1 | 2 | Marcela Martinez (COL)
|
4:47.13 | |
| 14 | 2 | 4 | Ayelen Becker (ARG)
|
4:52.23 | |
| 2 | 8 |  Karlene van der Jagt (SUR)
|
DNS |
Final
| Rank | Lane | Athlete | Result | Notes |
|---|---|---|---|---|
 |
5 | Joanna Maranhão (BRA)
|
4:13.79 | |
 |
4 | Kristel Kobrich (CHI)
|
4:15.26 | |
 |
3 | Cecilia Biagioli (ARG)
|
4:15.55 | |
| 4 | 6 | Yanel Pinto (VEN)
|
4:27.94 | |
| 5 | 1 | Nicole Maria Gilbert (ECU)
|
4:29.46 | |
| 6 | 8 | Andrea del Rosario Rodriguez (PER)
|
4:31.83 | |
| 7 | 7 | Darneyis Orozco (VEN)
|
4:34.13 | |
| 8 | 2 | Sarah Correa (BRA)
|
4:37.96 |