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Systemic administration is a route of administration of medication, nutrition or other substance into the circulatory system so that the entire body is affected. Administration can take place via enteral administration (absorption of the drug through the gastrointestinal tract) or parenteral administration (generally injection, infusion, or implantation).

Contrast with topical administration where the effect is generally local.

References

1. Hunnius Pharmazeutisches Wörterbuch (in German) (8th ed.). Berlin: Walter de Gruyter. 1998. p. 1477. ISBN 3-11-015793-4.
2. "Enteral administration - pharmacology". britannica.com. Retrieved 19 April 2018.
3. Hunnius Pharmazeutisches Wörterbuch (in German) (8th ed.). Berlin: Walter de Gruyter. 1998. pp. 472, 1029. ISBN 3-11-015793-4.
4. ^ Mutschler, Ernst (2013). Arzneimittelwirkungen (in German) (10 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 8. ISBN 978-3-8047-2898-1.

v t e Routes of administration, dosage forms
Oral	Digestive tract (enteral) Solids Tablet Capsule Pastille Time release technology Osmotic delivery system Liquids Decoction Elixir Electuary Emulsion Effervescent powder or tablet Herbal tea Hydrogel Molecular encapsulation Powder Softgel Solution Suspension Syrup Tincture Oral mucosa (buccal, sublabial, sublingual) Solids Orally disintegrating tablet Film Lollipop Sublingual drops Lozenges Effervescent tablet Chewing gum Liquids Mouthwash Toothpaste Ointment Spray Respiratory tract (inhalation) Solids Dry-powder inhaler Smoking 0 0 Liquids Anesthetic vaporizer Heated humidified high-flow therapy Medical inhalants Metered-dose inhaler (MDI) Nebulizer Vaporizer Gas Oxygen mask and Nasal cannula Oxygen concentrator Anaesthetic machine Medical inhalants Relative analgesia machine
Ophthalmic, otic, nasal	Nasal spray Ear drops Eye drops Ointment Hydrogel Insufflation Mucoadhesive microdisc
Urogenital	Ointment Pessary Vaginal ring Douche Intrauterine device (IUD) Extra-amniotic infusion Intravesical infusion
Rectal (enteral)	Ointment Suppository Enema Solution Hydrogel Murphy drip Nutrient enema
Dermal (topical)	Ointment Topical cream Topical gel Liniment Paste Film DMSO solution Iontophoresis Hydrogel Liposomes Transfersome vesicles Cream Lotion Lip balm Medicated shampoo Dermal patch Transdermal patch Transdermal spray Jet injector
Parenterals Injections infusions (into tissue/blood)	Skin (transdermal) Intradermal Subcutaneous Injector pen Transdermal implant Organs Intracavernous Intravitreal Intra-articular Central nervous system Intracerebral Intrathecal Epidural Circulatory, musculoskeletal Intravenous Intracardiac Intramuscular Intraosseous Intraperitoneal Nanocell injection Patient-controlled analgesia pump PIC line

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