Tŷ Mawr (sometimes Ty Mawr) means "big house" in Welsh and may refer to the following historical houses or areas in Wales:
- Tŷ Mawr, Castle Caereinion in Powys
- Tŷ Mawr, Dingestow in Monmouthshire
- Tŷ Mawr Wybrnant in Conwy County Borough
- Caeau Ty-mawr, a Site of Special Scientific Interest in Brecknock, Powys
- Holyhead Mountain Hut Circles (Welsh: Cytiau Tŷ Mawr), a group of prehistoric dwellings on Holy Island, Anglesey
- Tŷ Mawr, Wrexham, country park in Wrexham County Borough
- Ty Mawr Reservoir, reservoir in Wrexham County Borough
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