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Systematic IUPAC name (2R)-N--1-oxopropan-2-yl}amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl]-N-hydroxy-2-(2-methylpropyl)butanediamide | |
Other names N-{(2R)-2--4-methylpentanoyl}-3-(2-naphthyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide | |
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Chemical formula | C26H37N5O5 |
Molar mass | 499.612 g·mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references |
TAPI-1 ( TNF-alpha protease inhibitor I) is a structural analog of TAPI-0 with similar but more stable validness in vitro for the matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme which blocks shedding of several cell surface proteins such as IL-6 and p60 TNF receptor.
References
- Müllberg J rt al; Durie; Otten-Evans; Alderson; Rose-John; Cosman; Black; Mohler (Dec 1, 1995). "A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor". J Immunol. 155 (11): 5198–5205. doi:10.4049/jimmunol.155.11.5198. PMID 7594530.
- "TAPI-1 biological activity". selleckchemicals.