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TCL1B
Identifiers
Aliases	TCL1B, SYN-1, TML1, T-cell leukemia/lymphoma 1B, T cell leukemia/lymphoma 1B, TCL1 family AKT coactivator B
External IDs	OMIM: 603769; HomoloGene: 81735; GeneCards: TCL1B; OMA:TCL1B - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.13 Start 95,686,426 bp End 95,692,628 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad granulocyte lymph node placenta left testis tonsil right testis spleen blood n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase binding protein serine/threonine kinase activator activity Cellular component protein-containing complex Biological process positive regulation of peptidyl-serine phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9623 n/a Ensembl ENSG00000213231 n/a UniProt O95988 n/a RefSeq (mRNA) NM_199206 NM_004918 n/a RefSeq (protein) NP_004909 n/a Location (UCSC) Chr 14: 95.69 – 95.69 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

T-cell leukemia/lymphoma protein 1B is a protein that in humans is encoded by the TCL1B gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000213231 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (May 1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc Natl Acad Sci U S A. 96 (6): 2949–51. Bibcode:1999PNAS...96.2949P. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617.
4. "Entrez Gene: TCL1B T-cell leukemia/lymphoma 1B".

Further reading

• Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
• Laine J, Künstle G, Obata T, et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
• Saitou M, Sugimoto J, Hatakeyama T, et al. (2000). "Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia". Oncogene. 19 (23): 2796–802. doi:10.1038/sj.onc.1203604. PMID 10851082.
• Sugimoto J, Hatakeyama T, Narducci MG, et al. (1999). "Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus". Cancer Res. 59 (10): 2313–7. PMID 10344735.

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