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C13orf16

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(Redirected from TEX29) Protein in humans
TEX29
Identifiers
AliasesTEX29, C13orf16, bA474D23.1, testis expressed 29
External IDsHomoloGene: 51840; GeneCards: TEX29; OMA:TEX29 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)
Chromosome 13 (human)Genomic location for TEX29Genomic location for TEX29
Band13q34Start111,316,184 bp
End111,344,249 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • testicle

  • right testis

  • sperm

  • right frontal lobe

  • Brodmann area 9

  • cingulate gyrus

  • anterior cingulate cortex

  • gonad

  • prefrontal cortex
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

121793

n/a

Ensembl

ENSG00000153495

n/a

UniProt

Q8N6K0

n/a

RefSeq (mRNA)

NM_152324
NM_001303133

n/a

RefSeq (protein)

NP_001290062
NP_689537

n/a

Location (UCSC)Chr 13: 111.32 – 111.34 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

Chromosome 13 open reading frame 16 is a protein in homo sapiens encoded by the C13orf16 gene. There is one alias name, TEX29, for the high testis expression of this gene due to spermatogenesis.

C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34. The spliced gene is 859 nucleotides, has 7 exons and is located on the plus strand.

C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the hippocampus and cerebellum.

Protein

The human C13orf16 protein encoded by the mRNA sequence is 174 amino acids in length. The molecular weight without post-transitional modifications is 18.4 KD and the basal isoelectric point value is 4.99 pH.

Human C13orf16 is localized both intracellularly, in the nucleus, and extracellularly with one transmembrane domain from amino acids 80-102. There are no asparagines, resulting in no N-glycosylation sites.

There are five interacting proteins for human C13orf16, all identified by physical interactions.

Interacting proteins for human C13orf16 protein
Abbreviated Name Full Name Brief Description
PTS 6-Pyruvoyltetrahydropterin Synthase Elimination of inorganic triphosphate from dihydroneopterin triphosphate

(2nd and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP)

SLC16A2 Solute Carrier Family 16 Member 2 Non-redundant, thyroid hormone transporter
STEAP3 STEAP Family Member 3, Metalloreductase Iron transporter, can reduce both iron (Fe3+) and copper (Cu2+) cations
SLC4A7 Solute Carrier Family 4  Member 7 Sodium bicarbonate cotransporter, transports sodium and bicarbonate ions in a 1:1 ratio, considered an electroneutral cotransporter
SLC6A15 Solute Carrier Family 6 Member 15 Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport

Homology and evolution

The C13orf16 protein was only found to have orthologs in placental mammals and most distantly found in the Proboscidea taxonomic group. In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.

Orthologs of human C13orf16 protein
Genus & Species Common Name Taxonomic Group Date of Divergence (MYA) Accession Number Sequence Length (aa) Sequence Identity to Human Protein Sequence Similarity to Human Protein
Homo sapiens Human Primates 0 NP_001290062 174 100% 100%
Nomascus leucogenys Northern Gibbon Primates 19.5 XP_012362426 173 91% 94.80%
Macaca mulatta Rhesus Macaque Primates 28.8 XP_028693172 182 44.30% 51.70%
Cebus imitator White-faced Capuchin Primates 43 XP_037585341 179 70.60% 77.80%
Peromyscus maniculatus bairdii Deer Mouse Rodentia 87 XP_042118685 176 27.20% 38.60%
Peromyscus leucopus White-Footed Mouse Rodentia 87 XP_037067483 176 26.70% 38.60%
Oryctolagus cuniculus European Rabbit Lagomorpha 87 XP_051685630 143 25.80% 30.80%
Phoca vitulina Harbor Seal Carnivora 94 XP_032258415 162 34% 43.50%
Neofelis nebulosa Clouded Leopard Carnivora 94 XP_058598545 165 34.00% 45.20%
Phacochoerus africanus Warthog Artiodactyla 94 XP_047612273 171 32.10% 41.80%
Balaenoptera ricei Rice's Whale Artiodactyla 94 XP_059759229 147 29.30% 36.40%
Hyaena hyaena Striped Hyena Carnivora 94 XP_039082615 151 29.00% 39.40%
Ailuropoda melanoleuca Giant Panda Carnivora 94 XP_034521380 147 25% 31.20%
Hippopotamus amphibius kiboko East African Hippo Artiodactyla 94 XP_057563793 147 23.70% 34.30%
Artibeus jamaicensis Jamacian Fruit Bat Chiroptera 94 XP_036993559.2 149 21.70% 30.40%
Vulpes lagopus Arctic Fox Carnivora 94 XP_041586767 178 21.7%% 30.0%%
Equus caballus Horse Perissodactyla 94 XP_005601398 136 20.80% 27.00%
Talpa occidentalis Spanish Mole Talpidae 94 XP_037383406 162 19.30% 25.00%
Diceros bicornis minor Black Rhino Perissodactyla 94 XP_058403718 181 18.80% 24%
Elephas maximus indicus Indian Elephant Proboscidea 99 XP_049723476 145 23.80% 35.10%

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000153495 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Home - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  4. ^ "GeneCards". GeneCards. Retrieved December 13, 2024.
  5. "AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  6. ^ "Home - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  7. ^ "SAPS". www.ebi.ac.uk. Retrieved 2024-12-14.
  8. "PhosphoSitePlus". www.phosphosite.org. Retrieved 2024-12-14.
  9. ^ "GeneMANIA". genemania.org. Retrieved 2024-12-14.
  10. ^ "TEX29 Result Summary | BioGRID". thebiogrid.org. Retrieved 2024-12-14.
  11. "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  12. "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2024-12-14.
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