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TFEC
Identifiers
Aliases	TFEC, TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L, transcription factor EC
External IDs	OMIM: 604732; MGI: 1333760; HomoloGene: 32148; GeneCards: TFEC; OMA:TFEC - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q31.2 Start 115,935,148 bp End 116,159,896 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A2 Start 16,833,372 bp End 16,898,440 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte testicle granulocyte appendix kidney tubule bone marrow cells spleen lymph node jejunal mucosa upper lobe of left lung Top expressed in epithelium of small intestine migratory enteric neural crest cell proximal tubule stroma of bone marrow right kidney human kidney yolk sac morula efferent ductule granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription coactivator activity protein binding protein dimerization activity transcription corepressor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process cellular response to heat regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of nucleic acid-templated transcription transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22797 21426 Ensembl ENSG00000105967 ENSMUSG00000029553 UniProt O14948 Q9WTW4 RefSeq (mRNA) NM_001018058 NM_001244583 NM_012252 NM_031198 RefSeq (protein) NP_001018068 NP_001231512 NP_036384 NP_112475 Location (UCSC) Chr 7: 115.94 – 116.16 Mb Chr 6: 16.83 – 16.9 Mb PubMed search
Wikidata
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Transcription factor EC is a protein that in humans is encoded by the TFEC gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000105967 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029553 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
6. "Entrez Gene: TFEC transcription factor EC".

Further reading

• Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation". Mol. Cell. Biol. 13 (8): 4505–12. doi:10.1128/mcb.13.8.4505. PMC 360062. PMID 8336698.
• Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16. doi:10.1242/dev.125.23.4607. PMID 9806910.
• Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
• Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter". J. Leukoc. Biol. 71 (2): 304–10. doi:10.1189/jlb.71.2.304. PMID 11818452. S2CID 22801820.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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