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TGOLN2

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Protein-coding gene in the species Homo sapiens

TGOLN2

Identifiers

TGOLN2, TGN38, TGN46, TGN48, TGN51, TTGN2, trans-golgi network protein 2, hTGN46, hTGN48, hTGN51

External IDs

OMIM: 603062; HomoloGene: 136490; GeneCards: TGOLN2; OMA:TGOLN2 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p11.2	Start	85,318,027 bp
Band	2p11.2	End	85,328,251 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

renal medulla

parotid gland

caput epididymis

lateral nuclear group of thalamus

lactiferous duct

mucosa of sigmoid colon

lower lobe of lung

corpus epididymis

visceral pleura

Epithelium of choroid plexus

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	integral component of membrane trans-Golgi network Golgi apparatus trans-Golgi network transport vesicle transport vesicle membrane nucleoplasm cytosol plasma membrane clathrin-coated vesicle membrane endoplasmic reticulum lumen endosome
Biological process	Golgi to endosome transport membrane organization post-translational protein modification
Sources:Amigo / QuickGO

Species

Human

Mouse


10618


n/a


ENSG00000152291


n/a


O43493


n/a

RefSeq (mRNA)

NM_006464 NM_001206840 NM_001206841 NM_001206844 NM_001368095
NM_001368096


n/a

RefSeq (protein)

NP_001193769 NP_001193770 NP_001193773 NP_006455 NP_001355024
NP_001355025


n/a

Location (UCSC)

Chr 2: 85.32 – 85.33 Mb

n/a

PubMed search

n/a

View/Edit Human

Trans-Golgi network integral membrane protein 2 is a protein that in humans is encoded by the TGOLN2 gene.

References

^ GRCh38: Ensembl release 89: ENSG00000152291 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kain R, Angata K, Kerjaschki D, Fukuda M (Feb 1998). "Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs". J Biol Chem. 273 (2): 981–8. doi:10.1074/jbc.273.2.981. PMID 9422759.
"Entrez Gene: TGOLN2 trans-golgi network protein 2".

Further reading

Ohno H, Stewart J, Fournier MC, et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science. 269 (5232): 1872–5. Bibcode:1995Sci...269.1872O. doi:10.1126/science.7569928. PMID 7569928.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Ponnambalam S, Girotti M, Yaspo ML, et al. (1997). "Primate homologues of rat TGN38: primary structure, expression and functional implications". J. Cell Sci. 109 (3): 675–85. doi:10.1242/jcs.109.3.675. PMID 8907712.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". Biochem. J. 335 (Pt 3): 567–72. doi:10.1042/bj3350567. PMC 1219817. PMID 9794796.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
Wang J, Howell KE (2001). "The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking". Traffic. 1 (9): 713–23. doi:10.1034/j.1600-0854.2000.010904.x. PMID 11208159. S2CID 22784729.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yeaman C, Ayala MI, Wright JR, et al. (2004). "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network". Nat. Cell Biol. 6 (2): 106–12. doi:10.1038/ncb1090. PMC 3372901. PMID 14743217.
Höning S, Ricotta D, Krauss M, et al. (2005). "Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2" (PDF). Mol. Cell. 18 (5): 519–31. doi:10.1016/j.molcel.2005.04.019. hdl:11379/18706. PMID 15916959.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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