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THBS3
Identifiers
Aliases	THBS3, TSP3, thrombospondin 3
External IDs	OMIM: 188062; MGI: 98739; HomoloGene: 5159; GeneCards: THBS3; OMA:THBS3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 155,195,588 bp End 155,209,051 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 39.01 cM Start 89,122,487 bp End 89,134,144 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube tibia body of uterus right testis left testis right coronary artery left uterine tube tibial nerve tendon of biceps brachii canal of the cervix Top expressed in ventricular zone spermatocyte pulmonary alveolar epithelium lip ankle right lung lobe ankle joint esophagus efferent ductule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding extracellular matrix structural constituent Cellular component perinuclear region of cytoplasm extracellular region extracellular matrix extracellular space collagen-containing extracellular matrix Biological process growth plate cartilage development ossification involved in bone maturation cell-matrix adhesion cell adhesion bone trabecula formation extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7059 21827 Ensembl ENSG00000169231 ENSMUSG00000028047 UniProt P49746 Q05895 RefSeq (mRNA) NM_001252607 NM_001252608 NM_007112 NM_013691 RefSeq (protein) NP_001239536 NP_001239537 NP_009043 NP_038719 Location (UCSC) Chr 1: 155.2 – 155.21 Mb Chr 3: 89.12 – 89.13 Mb PubMed search
Wikidata
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Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000169231 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028047 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vos HL, Devarayalu S, de Vries Y, Bornstein P (June 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". The Journal of Biological Chemistry. 267 (17): 12192–12196. doi:10.1016/S0021-9258(19)49823-2. PMID 1601886.
6. ^ "Entrez Gene: THBS3 thrombospondin 3".
7. Hankenson KD, Hormuzdi SG, Meganck JA, Bornstein P (July 2005). "Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815.
8. Niemi ME, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, et al. (December 2021). "Mapping the human genetic architecture of COVID-19". Nature. 600 (7889): 472–477. Bibcode:2021Natur.600..472C. doi:10.1038/s41586-021-03767-x. PMC 8674144. PMID 34237774. S2CID 235776838.

Further reading

• O'Rourke KM, Laherty CD, Dixit VM (December 1992). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". The Journal of Biological Chemistry. 267 (35): 24921–24924. doi:10.1016/S0021-9258(19)73983-0. PMID 1459996.
• Adolph KW, Long GL, Winfield S, Ginns EI, Bornstein P (May 1995). "Structure and organization of the human thrombospondin 3 gene (THBS3)". Genomics. 27 (2): 329–336. doi:10.1006/geno.1995.1050. PMID 7558000.
• Qabar A, Derick L, Lawler J, Dixit V (May 1995). "Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues". The Journal of Biological Chemistry. 270 (21): 12725–12729. doi:10.1074/jbc.270.21.12725. PMID 7759526.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Qabar AN, Lin Z, Wolf FW, O'Shea KS, Lawler J, Dixit VM (January 1994). "Thrombospondin 3 is a developmentally regulated heparin binding protein". The Journal of Biological Chemistry. 269 (2): 1262–1269. doi:10.1016/S0021-9258(17)42252-6. PMID 8288588.
• Bornstein P, Devarayalu S, Edelhoff S, Disteche CM (March 1993). "Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene". Genomics. 15 (3): 607–613. doi:10.1006/geno.1993.1114. PMID 8468055.
• Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (October 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Research. 7 (10): 1020–1026. doi:10.1101/gr.7.10.1020. PMC 310674. PMID 9331372.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Adolph KW (May 1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochemical and Biophysical Research Communications. 258 (3): 792–796. doi:10.1006/bbrc.1999.0710. PMID 10329465.
• Adolph KW, Bornstein P (July 1999). "The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript". Molecular Cell Biology Research Communications. 2 (1): 47–52. doi:10.1006/mcbr.1999.0148. PMID 10527891.
• Carron JA, Hiscott P, Hagan S, Sheridan CM, Magee R, Gallagher JA (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". The International Journal of Biochemistry & Cell Biology. 32 (11–12): 1137–1142. doi:10.1016/S1357-2725(00)00065-0. PMID 11137453.
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S (June 2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". The International Journal of Biochemistry & Cell Biology. 34 (6): 588–593. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
• Dalla-Torre CA, Yoshimoto M, Lee CH, Joshua AM, de Toledo SR, Petrilli AS, et al. (October 2006). "Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma". BMC Cancer. 6: 237. doi:10.1186/1471-2407-6-237. PMC 1609181. PMID 17022822.

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